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In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> APOE4, the major genetic risk factor for Alzheimer’s disease (AD), and ABCA1, required for lipidation of APOE are gene products of the liver X receptor (LXR) receptor. LXR agonists have been validated in animal models as therapeutics for AD, atherosclerosis, and many other diseases. Clinical progress has been thwarted by unwanted hepatic lipogenesis. Structurally diverse LXR ligands were profile...

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Literature Corpus work
9e3d3860-f5ea-5b9a-aa52-6a11719115fe
DOI
10.1101/2025.09.12.675753
Open publication

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