Article

A fluorescent probe enables the discovery of improved antagonists targeting the intracellular allosteric site of the chemokine receptor CCR7

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Intracellularly acting ligands of G protein-coupled receptors (GPCRs) are gaining significant interest in GPCR drug discovery. In this study, we report the development of the fluorescent ligand Mz437 ( 4 ) targeting the CC chemokine receptor CCR7 at an intracellular allosteric site. We demonstrate its experimental power by applying 4 to identify two improved intracellular CCR7 antagonists, SLW...

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Literature Corpus work: 47ab49e3-6ba3-53df-8bab-d8e22254dfb0
DOI: 10.1101/2024.08.27.607356

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