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Article

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007

Estébanez-Perpiñá Eva, Arnold Leggy A, Jouravel Natalia, Togashi Marie, Blethrow Justin, Mar Ellena, Nguyen Phuong, Phillips Kevin J, Baxter John D, Webb Paul, Guy R Kiplin, Fletterick Robert J

Abstract excerpt

The development of nuclear hormone receptor antagonists that directly inhibit the association of the receptor with its essential coactivators would allow useful manipulation of nuclear hormone receptor signaling. We previously identified 3-(dibutylamino)-1-(4-hexylphenyl)-propan-1-one (DHPPA), an...

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Identifiers

PMID: 17823305
DOI: 10.1210/me.2007-0174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17823305-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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