Article

Clonal morphology-guided combination therapies overcome heterogeneity-driven drug tolerance

2026-02-03

Abstract excerpt

Tumor heterogeneity plays a critical role in tumor relapse and the development of drug resistance. Current personalized strategies, based on genetic profiling or bulk tumor drug sensitivity testing, offer limited clinical value as they overlook clonal heterogeneity. Here, through establishing primary tumor cell cultures from multiple metastatic sites, we observed that tumor cells exhibit high morphological plastic...

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Literature Corpus work: 30076ee3-b4e1-5ace-9dd3-b75e05e98a22
DOI: 10.64898/2026.01.31.703021

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