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Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

25 Nov 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of people and continues to cause massive global upheaval. Coronaviruses are positive-strand RNA viruses with an unusually large genome of ~30 kb. They express an RNA-dependent RNA polymerase and a cohort of other replication enzymes and supporting factors to transcribe and replicate their genomes. The proteins performing these...

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PMID: 34824452
DOI: 10.1038/s41580-021-00432-z

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