Article

Lovastatin, not simvastatin, corrects core phenotypes in the fragile X mouse model

2018-09-29

Abstract excerpt

The cholesterol-lowering drug lovastatin corrects neurological phenotypes in animal models of fragile X syndrome (FX), a commonly identified genetic cause of autism and intellectual disability. The therapeutic efficacy of lovastatin is being tested in clinical trials for FX, however the structurally similar drug simvastatin has been proposed as an alternative due to an increased potency and brain penetrance. Here,...

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Literature Corpus work: f97dfc02-b6fe-5434-83d9-cee4fca4b0f3
DOI: 10.1101/430348

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