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Article

Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model.

eNeuro - 1 Jan 2019

Muscas Melania, Louros Susana R, Osterweil Emily K

Abstract excerpt

The cholesterol-lowering drug lovastatin corrects neurological phenotypes in animal models of fragile X syndrome (FX), a commonly identified genetic cause of autism and intellectual disability (ID). The therapeutic efficacy of lovastatin is being tested in clinical trials for FX; however, the structurally similar drug simvastatin has been proposed as an alternative due to an increased potency and brain...

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Identifiers

PMID: 31147392
DOI: 10.1523/ENEURO.0097-19.2019
PMCID: PMC6565377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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