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A targeted, low-throughput compound screen in a <i>Drosophila</i> model of neurofibromatosis type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD)

2022-11-13

Abstract excerpt

Autism spectrum disorder (ASD) is a common neurodevelopmental condition for which there are no pharmacological therapies that effectively target its core symptomatology. Animal models of syndromic forms of ASD, such as neurofibromatosis type 1, may be of use in screening for such treatments. Drosophila larvae lacking Nf1 expression exhibit tactile hypersensitivity following mechanical stimulation, proposed to mi...

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Literature Corpus work
2ddd1d65-3b71-5d0c-ace3-4bf6792f2f8c
DOI
10.1101/2022.11.11.516139
Open publication

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