Article

Learning molecular traits of human pain disease via voltage-gated sodium channel structure renormalization

2025-02-21

Abstract excerpt

Mammalian neurophysiology vitally depends on the stable functioning of transmembrane, pore-forming voltage-sensing proteins known as voltage-gated sodium channels (NaVChs). Deciphering the principles of NaVCh spatial organization can illuminate fundamental structure-function aspects of pore-forming proteins and offer new opportunities for pharmacological treatment of associated diseases such as chronic pain. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f978564e-6acb-53a4-b785-3ddc43bff8d1
DOI: 10.1101/2025.02.19.639033

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Learning molecular traits of human pain disease via voltage-gated sodium channel structure renormalizationDOI 10.1101/2025.02.19.639033Read

Learning molecular traits of human pain disease via voltage-gated sodium channel structure renormalizationSemantic proximity Read

Hydropathicity-Based Prediction of Pain-Causing NaV1.7 VariantsSemantic proximity Read

Hydropathicity-based prediction of pain-causing NaV1.7 variants.Semantic proximity Read

TRPM8 protein dynamics correlates with ligand structure and cellular functionSemantic proximity Read

Thermodynamic Architecture and Conformational Plasticity of GPCRsSemantic proximity Read

Molecular insights from conformational ensembles via machine learningSemantic proximity Read

Outer Pore Collapse as a Potential Mechanism of Partial Loss of Pain in Nav1.7 M899ISemantic proximity Read

Kinetic Machine Learning Unravels Ligand-Directed Conformational Change of μ Opioid ReceptorSemantic proximity Read

Network topology of NaV1.7 mutations in sodium channel-related painful disorders.Semantic proximity Read

Deep Learning Models Capture Umbrella Sampling-Derived Energetic Trends: A Troponin C Case Study.Semantic proximity Read

State-dependent network connectivity determines gating in a K+ channel.Semantic proximity Read

Incorporating physics to overcome data scarcity in predictive modeling of protein function: a case study of BK channelsSemantic proximity Read