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Learning molecular traits of human pain disease via voltage-gated sodium channel structure renormalization

2025-03-26

Abstract excerpt

<title>Abstract</title> <p>Mammalian neurophysiology vitally depends on the stable functioning of transmembrane, pore-forming voltage-sensing proteins known as voltage-gated sodium channels (NaVChs). Deciphering the principles of NaVCh spatial organization can illuminate fundamental structure-function aspects of pore-forming proteins and offer new opportunities for pharmacological treatment of associated diseases...

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Literature Corpus work
d2542f27-990c-539b-9a0e-d125b3b5d2d8
DOI
10.21203/rs.3.rs-6025046/v1
Open publication

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