Article
Hydropathicity-based prediction of pain-causing NaV1.7 variants.
BMC bioinformatics - 23 Apr 2021
Xenakis Makros N, Kapetis Dimos, Yang Yang, Gerrits Monique M, Heijman Jordi, Waxman Stephen G, Lauria Giuseppe, Faber Catharina G, Westra Ronald L, Lindsey Patrick J, Smeets Hubert J
Abstract excerpt
BACKGROUND: Mutation-induced variations in the functional architecture of the NaV1.7 channel protein are causally related to a broad spectrum of human pain disorders. Predicting in silico the phenotype of NaV1.7 variant is of major clinical importance; it can aid in reducing costs of in vitro pathophysiological characterization of NaV1.7 variants, as well as, in the design of drug agents for counteracting...
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