Article

Outer Pore Collapse as a Potential Mechanism of Partial Loss of Pain in Nav1.7 M899I

2026-08-21

Abstract excerpt

Complete loss of function of the voltage-gated sodium channel subtype Nav1.7, encoded by SCN9A, results in congenital insensitivity to pain. Here, we investigate a previously identified variant, M899I, in which methionine at position 899 is substituted by isoleucine. This variant was originally described in a Chinese patient with loss of pain. We confirmed membrane expression of the mutant channel in HEK cells usi...

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Identifiers and source

Literature Corpus work: 98764285-887b-5ca0-9727-404770fc27e4
DOI: 10.64898/2026.08.18.745213

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