Article

A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score

2018-04-23

Abstract excerpt

Previously described methods of analysis allow variants in a gene to be weighted more highly according to rarity and/or predicted function and then for the variant contributions to be summed into a gene-wise risk score which can be compared between cases and controls using a t test. However this does not allow incorporating covariates into the analysis. Schizophrenia is an example of an illness where there is evid...

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Literature Corpus work: f954226d-0637-5f90-a635-9f36c35efd67
DOI: 10.1101/306191

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