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Article

Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology.

Behavior genetics - 1 May 2018

Curtis David, Coelewij Leda, Liu Shou-Hwa, Humphrey Jack, Mott Richard

Abstract excerpt

A previous study of exome-sequenced schizophrenia cases and controls reported an excess of singleton, gene-disruptive variants among cases, concentrated in particular gene sets. The dataset included a number of subjects with a substantial Finnish contribution to ancestry. We have reanalysed the same dataset after removal of these subjects and we have also included non-singleton variants of all types using a...

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Identifiers

PMID: 29564678
DOI: 10.1007/s10519-018-9893-3
PMCID: PMC5934462

Genes

FYN
GRIN1

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