Article

Trypsin Enhances SARS-CoV-2 Infection by Facilitating Viral Entry

2021-10-18

Abstract excerpt

<title>Abstract</title> <p>Coronavirus infects the cell by cytoplasmic or endosomal membrane fusion driven by the spike (S) protein, which must be primed by proteolytic cleavage at the S1/S2 furin cleavage site (FCS) and S2′ site by cellular proteases. Exogenous trypsin as a medium additive facilitates isolation and propagation of several coronaviruses <italic>in vitro</italic>. Here, we showed that trypsin media...

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Literature Corpus work: f9498d7e-4ec5-5b9c-af84-091063a1f67c
DOI: 10.21203/rs.3.rs-919057/v1

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