Article

Genome-Wide mRNA Profiling Identifies X-Box-Binding Protein 1 (XBP1) As An IRE1 And PUMA Repressor

2021-05-27

Abstract excerpt

<title>Abstract</title> <p>Accumulation of misfolded proteins in ER activates the unfolded protein response (UPR), a multifunctional signaling pathway that is important for cell survival. The UPR is regulated by three ER transmembrane sensors, one of which is inositol-requiring protein 1 (IRE1). IRE1 activates a transcription factor, X-box binding protein 1 (<italic>XBP1)</italic>, by removing a 26-base intron fr...

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Literature Corpus work: 13b00b94-2a0e-513f-8213-936d911f17bb
DOI: 10.21203/rs.3.rs-527235/v1

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