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Article

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.

Nature chemical biology - 1 Dec 2012

Wang Likun, Perera B Gayani K, Hari Sanjay B, Bhhatarai Barun, Backes Bradley J, Seeliger Markus A, Schürer Stephan C, Oakes Scott A, Papa Feroz R, Maly Dustin J

Abstract excerpt

Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α. IRE1α oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Here we show that IRE1α's kinase-controlled RNase can be regulated in two distinct modes with kinase inhibitors: one class of...

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Identifiers

PMID: 23086298
DOI: 10.1038/nchembio.1094
PMCID: PMC3508346

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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