Article

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

2021-12-30

Abstract excerpt

<h4>SUMMARY</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed over 6 million individuals worldwide and continues to spread in countries where vaccines are not yet widely available, or its citizens are hesitant to become vaccinated. Therefore, it is critical to unravel the molecular mechanisms that allow SARS-CoV-2 and other coronaviruses to infect and overtake the host machinery of huma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 467b8909-8d18-52bd-8f8e-426991aa66c8
DOI: 10.1101/2021.12.30.474519

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cellsDOI 10.1101/2021.12.30.474519Read

Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung Derived Cell LinesSemantic proximity Read

The Role of Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug DesignSemantic proximity Read

IRE1α-XBP1 Activation Elicited by Viral Singled Stranded RNA via <i>TLR8</i> May Modulate Lung Cytokine Induction in SARS-CoV-2 PneumoniaSemantic proximity Read

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infectionSemantic proximity Read

Coronavirus infection, ER stress, apoptosis and innate immunitySemantic proximity Read

The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infectionSemantic proximity Read

Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum StressSemantic proximity Read

Human Coronavirus: Host-Pathogen InteractionSemantic proximity Read

Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virusSemantic proximity Read

Deleterious effects of SARS-CoV-2 infection on human pancreatic cellsSemantic proximity Read

A topology-dependent IRE1α signaling axis generates a cryptic XBP1 isoform present in human cancersSemantic proximity Read

Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactionsSemantic proximity Read