Article

Intranasal CRISPR- lipid nanoparticles targeting MAPK9 reduce neuroinflammation after traumatic brain injury

2026-04-26

Abstract excerpt

Traumatic brain injury (TBI) triggers a sustained neuroinflammatory response driven by activated microglia, which contributes to secondary injury and long-term neurological dysfunction. Therapeutic reprogramming of microglial activation from a pro-inflammatory (M1-like) to a reparative (M2-like) phenotype represents a promising strategy; however, the lack of cell-specific targeting within an injured brain has limi...

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Literature Corpus work: f91dfb49-ea7e-50ea-8bdc-b3a7c01f705f
DOI: 10.64898/2026.04.25.720847

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