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Article

CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2021

Li Xinyu, Kang Jianning, Lv Hong, Liu Ronghan, Chen Jianan, Zhang Yining, Zhang Ying, Yu Guilian, Zhang Xiaodi, Ning Bin

Abstract excerpt

Spinal cord injury (SCI) is a complex pathological change that includes primary SCI and gradually evolves into secondary SCI. Accumulating evidence demonstrates that circular RNAs (circRNAs) are involved in the pathology of a variety of neurological diseases and injuries. However, the characteristics and function of circRNAs in SCI have yet to be elucidated. Although previous research demonstrated that circPrkcsh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34751973
DOI: 10.1096/fj.202100993R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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