Article
Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Nov 2021
Pu Hongjian, Ma Cheng, Zhao Yongfang, Wang Yangfan, Zhang Wenting, Miao Wanying, Yu Fang, Hu Xiaoming, Shi Yejie, Leak Rehana K, Hitchens T Kevin, Dixon C Edward, Bennett Michael Vl, Chen Jun
Abstract excerpt
Traumatic brain injury (TBI) is commonly followed by long-term cognitive deficits that severely impact the quality of life in survivors. Recent studies suggest that microglial/macrophage (Mi/MΦ) polarization could have multidimensional impacts on post-TBI neurological outcomes. Here, we report that repetitive intranasal delivery of interleukin-4 (IL-4) nanoparticles for 4 weeks after controlled cortical impact...
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