Article

Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism

2021-03-03

Abstract excerpt

ABCG2 is a multidrug transporter expressed widely in the human body. Its physiological substrates include steroid derivatives and uric acid. In addition, it extrudes many structurally diverse cytotoxic drugs from various cells, thus affecting drug pharmacokinetics and contributing to multidrug resistance of cancer cells. Previous studies have revealed structures of ABCG2 bound to transport substrates, nucleotides,...

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Literature Corpus work: f9166f24-6efd-54d8-bd77-c9c5c407ed53
DOI: 10.1101/2021.03.03.433600

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