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Article

The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes.

Psychopharmacology - 1 Jun 2015

Jiang Fen, Kim Hae-Deun, Na Han-Sung, Lee Seok-Yong, Seo Doo-Won, Choi Jong-Yeol, Ha Ji-Hye, Shin Hee-Jung, Kim Young-Hoon, Chung Myeon-Woo

Abstract excerpt

RATIONALE: Two biomarkers: concentration ratio of O-desmethylvenlafaxine/venlafaxine and concentration sum of venlafaxine + O-desmethylvenlafaxine were adopted to indicate venlafaxine responses, but neither is validated. OBJECTIVES: To evaluate the ability of two biomarkers in reflecting venlafaxine pharmacokinetic variations, and to further examine their relationship with venlafaxine treatment outcomes. METHODS:...

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PMID: 25510856
DOI: 10.1007/s00213-014-3825-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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