Article

Response to “Expression reduction of biallelically transcribed X-linked genes during the female human preimplantation development”

2019-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Reinius and Sandberg (2019) have recently shown that X-linked balletic gene expression decreases during human preimplantation embryonic development, corroborating their previous hypothesis of X dampening as a mechanism of dosage compensation. Here we demonstrate that their analyses are based on biologically false premises, thus not demonstrating the phenomena of X dampening in humans.

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f90d1c16-1770-56cd-a3b5-4fa5c64e13e5
DOI: 10.1101/701227

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Response to “Expression reduction of biallelically transcribed X-linked genes during the female human preimplantation development”DOI 10.1101/701227Read

Expression reduction of biallelically transcribed X-linked genes during the human female preimplantation developmentSemantic proximity Read

Dosage sensitivity of X-linked genes in human embryonic single cellsSemantic proximity Read

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.Semantic proximity Read

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete.Semantic proximity Read

Single Cell Analysis Reveals Partial Reactivation of X-chromosome Instead of Chromosome-wide Dampening in Naïve Human Pluripotent Stem CellsSemantic proximity Read

The human Y and inactive X chromosomes similarly modulate autosomal gene expressionSemantic proximity Read

X-chromosome inactivation and its implications for human diseaseSemantic proximity Read

Dynamic X-chromosomal reactivation enhances female brain resilienceSemantic proximity Read