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Article

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete.

PLoS genetics - 1 Jan 2008

Johnston Colette M, Lovell Frances L, Leongamornlert Daniel A, Stranger Barbara E, Dermitzakis Emmanouil T, Ross Mark T

Abstract excerpt

X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage...

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Share to Chromosomes, Human, X
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dosage Compensation, Genetic

Share to Genes, X-Linked

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Source

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Identifiers

PMID: 18208332
DOI: 10.1371/journal.pgen.0040009
PMCID: PMC2213701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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