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Article

Impact of resistance mutations on inhibitor binding to HIV-1 integrase.

Journal of chemical information and modeling - 23 Dec 2013

Chen Qi, Buolamwini John K, Smith Jeremy C, Li Aixiu, Xu Qin, Cheng Xiaolin, Wei Dongqing

Abstract excerpt

HIV-1 integrase (IN) is essential for HIV-1 replication, catalyzing two key reaction steps termed 3' processing and strand transfer. Therefore, IN has become an important target for antiviral drug discovery. However, mutants have emerged, such as E92Q/N155H and G140S/Q148H, which confer resistance to raltegravir (RAL), the first IN strand transfer inhibitor (INSTI) approved by the FDA, and to the recently...

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Identifiers

PMID: 24205814
DOI: 10.1021/ci400537n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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