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Article

Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors.

Journal of molecular biology - 1 Sept 2025

Montermoso Saira, Eilers Grant, Allen Audrey, Sharp Robert, Hwang Young, Bushman Frederic D, Gupta Kushol, Duyne Gregory Van

Abstract excerpt

HIV-1 integrase (IN) is targeted by two classes of antivirals: integrase strand transfer inhibitors (INSTIs), which bind to the active site within the catalytic core domain (CCD), and allosteric integrase inhibitors (ALLINIs), which bind at the CCD dimer interface. ALLINIs were initially designed to disrupt interactions with the cellular cofactor LEDGF/p75, but it has become clear that ALLINIs primarily act by...

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Share to Allosteric Regulation
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Drug Resistance, Viral

Share to HIV Integrase

Share to HIV Integrase Inhibitors

Share to Protein Multimerization

Source

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Identifiers

PMID: 40409709
DOI: 10.1016/j.jmb.2025.169224
PMCID: PMC13062980

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