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Article

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.

Science advances - 21 Jul 2023

Li Min, Oliveira Passos Dario, Shan Zelin, Smith Steven J, Sun Qinfang, Biswas Avik, Choudhuri Indrani, Strutzenberg Timothy S, Haldane Allan, Deng Nanjie, Li Zhaoyang, Zhao Xue Zhi, Briganti Lorenzo, Kvaratskhelia Mamuka, Burke Terrence R, Levy Ronald M, Hughes Stephen H, Craigie Robert, Lyumkis Dmitry

Abstract excerpt

HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is mediated by the viral enzyme integrase and is blocked by integrase strand transfer inhibitors (INSTIs), first-line antiretroviral therapeutics widely used in the clinic. Resistance to even the best INSTIs is a problem, and the mechanisms of resistance are poorly understood. Here, we analyze combinations of the mutations...

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Identifiers

PMID: 37478179
DOI: 10.1126/sciadv.adg5953
PMCID: PMC11803526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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