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Article

Resistance to Integrase Inhibitors

25 Jun 2010

Abstract excerpt

Integrase (IN) is a clinically validated target for the treatment of human immunodeficiency virus infections and raltegravir exhibits remarkable clinical activity. The next most advanced IN inhibitor is elvitegravir. However, mutant viruses lead to treatment failure and mutations within the IN coding sequence appear to confer cross-resistance. The characterization of those mutations is critical for the...

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PMID: 20706558
DOI: 10.3390/v2071347

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