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Article

JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases

7 Mar 2025

Abstract excerpt

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing a critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions...

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PMID: 40055704
DOI: 10.1186/s12935-025-03681-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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