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UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling.

Cell - 6 Aug 2026

Li Yiming, Zeng Min, Zhu Jun, Liu Linjing, Wang Fang, Huang Longkai, Yang Fan, Li Min, Yao Jianhua

Abstract excerpt

Systematically simulating and predicting phenotypic effects of diverse interventions across heterogeneous cellular environments is central to the vision of artificial intelligence virtual cell (AIVC). However, disparities in perturbagen modalities, assay formats, and data production efficiency hinder unified modeling and analysis of genetic and chemical screens. This study presents UniPert-G2CP, a two-stage deep...

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PMID: 42497867
DOI: 10.1016/j.cell.2026.06.005

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