Article

Platelet Activating Factor Activity Modulates Hyperoxic Neonatal Lung Injury Severity

2023-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Hyperoxia-induced inflammation contributes significantly to developmental lung injury and bronchopulmonary dysplasia (BPD) in preterm infants. Platelet activating factor (PAF) is known to be a major driver of inflammation in lung diseases such as asthma and pulmonary fibrosis, but its role in BPD has not been previously investigated. Therefore, to determine whether PAF signaling independently mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8e836a4-f3ff-57a1-9e8d-a72d668dc7db
DOI: 10.1101/2023.03.14.532697

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Platelet Activating Factor Activity Modulates Hyperoxic Neonatal Lung Injury SeverityDOI 10.1101/2023.03.14.532697Read

Remarkable sex-specific differences at Single-Cell Resolution in Neonatal Hyperoxic Lung InjurySemantic proximity Read

Loss of Surfactant Protein a Alters Perinatal Lung Morphology and Susceptibility to Hyperoxia-Induced Bronchopulmonary DysplasiaSemantic proximity Read

Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasiaSemantic proximity Read

Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasiaSemantic proximity Read

Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injurySemantic proximity Read

A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severitySemantic proximity Read

Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure.Semantic proximity Read

A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severitySemantic proximity Read

Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight InfantsSemantic proximity Read

Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasiaSemantic proximity Read

Lung mesenchymal cell diversity rapidly increases at birth and is profoundly altered by hyperoxiaSemantic proximity Read

Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasiaSemantic proximity Read