Article

Loss of Surfactant Protein a Alters Perinatal Lung Morphology and Susceptibility to Hyperoxia-Induced Bronchopulmonary Dysplasia

2024-10-02

Abstract excerpt

<h4>Background: </h4> -Bronchopulmonary dysplasia (BPD) is a condition of poor alveolar formation that causes chronic breathing impairment in infants born prematurely. Preterm lungs lack surfactant and are vulnerable to oxidative injuries driving the development of BPD. Our recent studies reported that surfactant protein A (SP-A) genetic variants influence susceptibility to neonatal lung disease. SP-A modulates ac...

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Literature Corpus work: 5f0b8f18-701d-5e6c-aed7-75b726ee02a5
DOI: 10.20944/preprints202410.0150.v1

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