Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

11 Sept 2012

Abstract excerpt

Extra chromosome copies markedly alter the physiology of eukaryotic cells, but the underlying reasons are not well understood. We created human trisomic and tetrasomic cell lines and determined the quantitative changes in their transcriptome and proteome in comparison with their diploid counterparts. We found that whereas transcription levels reflect the chromosome copy number changes, the abundance of some...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Microtubule and mitosis dynamics
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22968442
DOI: 10.1038/msb.2012.40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cellsPMID 22968442Read ↗

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid CellsSemantic proximity Read ↗

Aneuploidy triggers a TFEB-mediated lysosomal stress responseSemantic proximity Read ↗

Regulation of protein complex partners as a compensatory mechanism in aneuploid tumorsSemantic proximity Read ↗

Regulation of protein complex partners as a compensatory mechanism in aneuploid tumorsSemantic proximity Read ↗

Consequences of aneuploidy in human fibroblasts with trisomy 21Semantic proximity Read ↗

Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell linesSemantic proximity Read ↗

Consequences of aneuploidy in human fibroblasts with trisomy 21Semantic proximity Read ↗

Effects of aneuploidy on gene expression: implications for cancer.Semantic proximity Read ↗

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cellsSemantic proximity Read ↗

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses.Semantic proximity Read ↗

Aneuploidy: implications for protein homeostasis and disease.Semantic proximity Read ↗

The Hallmarks of Aneuploidy in Cancer and Congenital SyndromesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.