Article

A Yersinia effector activates JAK-STAT signaling in human macrophages

2023-05-09

Abstract excerpt

The multifunctional Yersinia effector YopM inhibits effector triggered immunity and increases production of the anti-inflammatory cytokine Interleukin-10 (IL-10) to suppress the host immune response. Previously it was shown that YopM induces IL-10 gene expression by elevating phosphorylation of the serine-threonine kinase RSK1 in the nucleus of human macrophages. Using transcriptomics, we now show that YopM affec...

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Literature Corpus work: f8e0936d-f03d-567e-ac6e-9189ee911877
DOI: 10.1101/2023.05.08.539843

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