Article

Immune activation of primary human macrophages is suppressed by the coordinated action of <i>Yersinia</i> effectors

2025-05-17

Abstract excerpt

In order to suppress the host immune response, numerous bacterial pathogens utilise a type 3 secretion system (T3SS) that injects effector proteins into host target cells. We investigated the T3SS effectors of Yersinia enterocolitica (Yops) for their individual and combined effects on gene expression, inflammasome formation and calcium signaling in primary human macrophages. YopP efficiently suppressed the up- an...

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Literature Corpus work: 6c5270c7-d777-5d3a-a496-f0b34d2afa2e
DOI: 10.1101/2025.05.12.653505

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