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Defining a Midgestational Window for <i>In Utero</i> Genome Editing of the Fetal Murine Cortex

2026-05-01

Abstract excerpt

Congenital disorders of cortical development arise from genetic lesions that disrupt neurogenesis and neuronal migration. Unfortunately, tools to model or correct these defects before birth are limited. Here we establish a platform for systemic in utero gene delivery and genome editing in the mouse cortex at midgestation. By microdissecting a uterine window over the vitelline vein at embryonic day 12.5 (E12.5), w...

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Identifiers and source

Literature Corpus work
f8b78881-3f80-54c0-a866-0ffcefa387ed
DOI
10.64898/2026.04.28.721509
Open publication

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Defining a Midgestational Window for <i>In Utero</i> Genome Editing of the Fetal Murine CortexDOI 10.64898/2026.04.28.721509
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