Article

GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers

2025-04-16

Abstract excerpt

<h4>Summary</h4> WNT4 is critical for epithelial side branching in the mammary gland. In both mice and humans, its expression is tightly regulated and restricted to hormone-responsive, mature luminal cells. Although generally assumed to act downstream of progesterone, the molecular mechanisms that control lineage-specific induction of WNT4 gene expression remain unknown. Here we functionally dissect the cis...

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Literature Corpus work: f8b1e1b9-f1dc-53d9-a05e-798d7e6ace6b
DOI: 10.1101/2025.04.11.648333

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GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancersDOI 10.1101/2025.04.11.648333Read

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