Article
Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters.
Molecular cell - 1 Feb 2018
Grunseich Christopher, Wang Isabel X, Watts Jason A, Burdick Joshua T, Guber Robert D, Zhu Zhengwei, Bruzel Alan, Lanman Tyler, Chen Kelian, Schindler Alice B, Edwards Nancy, Ray-Chaudhury Abhik, Yao Jianhua, Lehky Tanya, Piszczek Grzegorz, Crain Barbara, Fischbeck Kenneth H, Cheung Vivian G
Abstract excerpt
R-loops are three-stranded nucleic acid structures found abundantly and yet often viewed as by-products of transcription. Studying cells from patients with a motor neuron disease (amyotrophic lateral sclerosis 4 [ALS4]) caused by a mutation in senataxin, we uncovered how R-loops promote transcription. In ALS4 patients, the senataxin mutation depletes R-loops with a consequent effect on gene expression. With fewer...
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