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Article

ALS: a disease of motor neurons and their nonneuronal neighbors.

Neuron - 5 Oct 2006

Boillée Séverine, Vande Velde Christine, Cleveland Don W

Abstract excerpt

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of instances are due to mutations in Cu/Zn superoxide dismutase (SOD1). Since sporadic and familial ALS affects the same neurons with similar pathology, it is hoped that therapies effective in mutant SOD1 models will translate to sporadic ALS. Mutant...

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Source

Identifiers

PMID: 17015226
DOI: 10.1016/j.neuron.2006.09.018

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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