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History of ALS and the competing theories on pathogenesis: IFCN handbook chapter

12 Dec 2023

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder of the human motor system, first described in the 19th Century. The etiology of ALS appears to be multifactorial, with a complex interaction of genetic, epigenetic, and environmental factors underlying the onset of disease. Importantly, there are no known naturally occurring animal models, and transgenic mouse models fail to...

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PMID: 38213309
DOI: 10.1016/j.cnp.2023.11.004

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