Article

Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic Diseases

2025-02-08

Abstract excerpt

The classical paradigm of drug screening often faces significant limitations due to the challenges associated with identifying molecular or cellular read-outs that are relevant to specific diseases. This issue is particularly pronounced for the thousands of diseases of genetic origin, given the abundance of databases listing disease-associated changes in gene expression and various transcripts, indicating that pot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f88d5e90-cb53-5913-aaf4-97d15e9c7810
DOI: 10.1101/2025.02.04.636445

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic DiseasesDOI 10.1101/2025.02.04.636445Read

Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative DiseasesSemantic proximity Read

Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral SclerosisSemantic proximity Read

Answer ALS: A Large-Scale Resource for Sporadic and Familial ALS Combining Clinical Data with Multi-Omics Data from Induced Pluripotent Cell LinesSemantic proximity Read

Toxicogenomic identification of repositioned therapy for a monogenic diseaseSemantic proximity Read

Screening for variable drug responses using human iPSC cohortsSemantic proximity Read

Gene Expression Profiles in Sporadic ALS Fibroblasts Define Disease Subtypes and The Metabolic Effects of the Investigational Drug EH301Semantic proximity Read

iPSC-Derived Myogenic Progenitor Cells from People with ME/CFS Reveal Altered Genes and Pathways with Drug Repurposing PotentialSemantic proximity Read

Statistical integration of multi-omics and drug screening data from cell linesSemantic proximity Read

iPSC-Derived Myogenic Progenitor Cells from People with ME/CFS Reveal Altered Genes and Pathways with Drug Repurposing PotentialSemantic proximity Read

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patientsSemantic proximity Read

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues.Semantic proximity Read