Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues.

Scientific reports - 8 Nov 2016

Kumar Vinod, Sanseau Philippe, Simola Daniel F, Hurle Mark R, Agarwal Pankaj

Abstract excerpt

It is commonly assumed that drug targets are expressed in tissues relevant to their indicated diseases, even under normal conditions. While multiple anecdotal cases support this hypothesis, a comprehensive study has not been performed to verify it. We conducted a systematic analysis to assess gene and protein expression for all targets of marketed and phase III drugs across a diverse collection of normal human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials, Phase III as Topic
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Genetic Predisposition to Disease

Share to Molecular Targeted Therapy

Share to Oligonucleotide Array Sequence Analysis

Share to Organ Specificity

Share to Proteomics

Source

Open in PubMed Open full text

Identifiers

PMID: 27824084
DOI: 10.1038/srep36205
PMCID: PMC5099936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues.PMID 27824084Read ↗

Tissue-specific genes as an underutilized resource in drug discoverySemantic proximity Read ↗

A compendium of gene expression in normal human tissues.Semantic proximity Read ↗

Investigating normal human gene expression in tissues with high-throughput transcriptomic and proteomic dataSemantic proximity Read ↗

Genes and Diseases: Insights from Transcriptomics Studies.Semantic proximity Read ↗

Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets.Semantic proximity Read ↗

TiSGeD: a database for tissue-specific genesSemantic proximity Read ↗

Large-scale assessment of pros and cons of autopsy-derived or tumor-matched tissues as the norms for gene expression analysis in cancersSemantic proximity Read ↗

The Gene Expression Landscape of Disease GenesSemantic proximity Read ↗

A systematic survey of human tissue-specific gene expression and splicing reveals new opportunities for therapeutic target identification and evaluationSemantic proximity Read ↗

A deep proteome and transcriptome abundance atlas of 29 healthy human tissuesSemantic proximity Read ↗

Robust and Rigorous Identification of Tissue-Specific Genes by Statistically Extending Tau ScoreSemantic proximity Read ↗

Analyzing cancer gene expression data through the lens of normal tissue-specificitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.