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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

13 Oct 2021

Abstract excerpt

and control motor neurons. Many individual -omics differed by protocol, but some core dysregulated pathways were consistent. This strategy of analyzing patient-specific neurons provides disease-related outcomes with small numbers of heterogeneous lines and reduces variation from single-omics to elucidate network-based signatures.

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PMID: 34746695
DOI: 10.1016/j.isci.2021.103221

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