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Article

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.

The Journal of clinical investigation - 2 Apr 2018

Khan Omar M, Carvalho Joana, Spencer-Dene Bradley, Mitter Richard, Frith David, Snijders Ambrosius P, Wood Stephen A, Behrens Axel

Abstract excerpt

The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the presence of FBW7 mRNA. To understand the molecular mechanism of FBW7 regulation in these cancers, we employed proteomics and identified the deubiquitinase (DUB) USP9X as an FBW7 interactor....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29346117
DOI: 10.1172/JCI97325
PMCID: PMC5873885

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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