Article

Dynamic HSF2 regulation drives breast cancer progression by steering the balance between proliferation and invasion

2024-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Phenotypic plasticity is a hallmark of breast carcinogenesis that facilitates the acquisition of invasive properties via epithelial-mesenchymal transition (EMT). Transforming growth factor-beta (TGF-β), a key EMT-inducing cytokine, drives pro-metastatic gene programs through downstream transcription factors. Among mammalian stress-protective transcription factors, heat shock factor 2 (HSF2) has...

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Literature Corpus work: f871be01-dcd2-5f5f-b862-da284b9897b0
DOI: 10.1101/2024.06.24.600354

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