Back to search

Article

Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma

2025-06-12

Abstract excerpt

Sub-populations of cancer-associated fibroblast (CAF)-like tumor cells deposit extracellular matrix (ECM) proteins that support Ewing sarcoma (EwS) progression and metastasis. We previously showed a hallmark of CAF-like EwS cells is their hybrid transcriptional state wherein the driver fusion oncogene, EWS::FLI1, maintains activation of proliferative programs but loses capacity to repress mesenchymal genes. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5db8f25f-0a27-57ff-9b04-a9f6c82fb08e
DOI
10.1101/2025.06.11.653876
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcomaDOI 10.1101/2025.06.11.653876
Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironmentSemantic proximity
A logical model of Ewing sarcoma cell epithelial-to-mesenchymal transition supports the existence of hybrid cellular phenotypes.Semantic proximity
The importance of fusion protein activity in Ewing sarcoma and the cell intrinsic and extrinsic factors that regulate it: A reviewSemantic proximity
EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity
Cancer-Associated Fibroblast-Like Tumor Cells Remodel the Ewing Sarcoma Tumor MicroenvironmentSemantic proximity
Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressivenessSemantic proximity
The impact and outcomes of cancer-macrophage fusionSemantic proximity
Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical DeterminantSemantic proximity
The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cellsSemantic proximity
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcomaSemantic proximity
Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancerSemantic proximity
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblastsSemantic proximity
Select a neighboring publication to make it the new centre.