Article

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

2022-03-11

Abstract excerpt

While the lung bears significant regenerative capacity, severe viral pneumonia can chronically impair lung function by triggering dysplastic remodeling. The connection between these enduring changes and chronic disease remains poorly understood. We recently described the emergence of tuft cells within Krt5 + dysplastic regions after influenza injury. Using bulk and single cell transcriptomics, we characterized an...

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Literature Corpus work: a58f7fcd-9276-5b5e-a670-04b34f8d349f
DOI: 10.1101/2022.03.10.483754

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