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Dysregulation of brain dopamine systems in major depressive disorder

16 Feb 2021

Abstract excerpt

Major depressive disorder (MDD or depression) is a debilitating neuropsychiatric syndrome with genetic, epigenetic, and environmental contributions. Depression is one of the largest contributors to chronic disease burden; it affects more than one in six individuals in the United States. A wide array of cellular and molecular modifications distributed across a variety of neuronal processes and circuits underlie...

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PMID: 33593109
DOI: 10.1177/1535370221991830

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