Article

Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction

2002-04-01

Abstract excerpt

The access of testosterone and estradiol to target tissues is regulated by sex hormone–binding globulin (SHBG) in human blood. Serum SHBG levels are low in patients with hyperandrogenism, especially in association with polycystic ovarian syndrome (PCOS) and in individuals at risk for diabetes and heart disease. Here, we identify SHBG coding region variations from a compound heterozygous patient who presented with...

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Literature Corpus work: f85d8b2d-bc35-541f-a7f9-f0c86b5a8684
DOI: 10.1172/jci0214060

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